Sleep Spray

Vor dem Schlafengehen eine Tagesdosis in den Mund, vorrangig unter die Zunge. Flüssigkeit einige Sekunden im Mund verweilen lassen und danach schlucken.

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1. Melatonin trägt dazu bei, die Einschlafzeit zu verkürzen. Die positive Wirkung stellt sich ein, wenn kurz vor dem Schlafengehen 1 mg Melatonin aufgenommen wird.
2. Vitamin B6 trägt zur Verringerung von Müdigkeit und Ermüdung bei.
3. Vitamin B6 trägt zu einem normalen Energiestoffwechsel bei.
4. EFSA Journal 2011 ;9(6):2241
5. EFSA Journal 2010 ; 8(2):1467
6. Yin, Jiawei, et al. "Relationship of sleep duration with all‐cause mortality and cardiovascular events: a systematic review and dose‐response meta‐analysis of prospective cohort studies." Journal of the American Heart Association 6.9 (2017): e005947
7. Jåbekk, Pål, et al. "A randomized controlled pilot trial of sleep health education on body composition changes following 10 weeks resistance exercise." The Journal of Sports Medicine and Physical Fitness (2020).
8. Kline, Christopher E., et al. "The association between sleep health and weight change during a 12-month behavioral weight loss intervention." International Journal of Obesity 45.3 (2021): 639-649.
9. Antza, Christina, et al. "The links between sleep duration, obesity and type 2 diabetes mellitus." Journal of Endocrinology 252.2 (2022): 125-141.
10. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). "Scientific Opinion on the substantiation of a health claim related to melatonin and reduction of sleep onset latency (ID 1698, 1780, 4080) pursuant to Article 13 (1) of Regulation (EC) No 1924/2006." EFSA Journal 9.6 (2011): 2241.
11. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). EFSA Journal 8.2 (2010): 1467. "Scientific Opinion on the substantiation of health claims related to melatonin and alleviation of subjective feelings of jet lag (ID 1953), and reduction of sleep onset latency, and improvement of sleep quality (ID 1953) pur
12. Guan, Qingyun, et al. "Mechanisms of Melatonin in Obesity: A Review." International Journal of Molecular Sciences 23.1 (2022): 218.
13. Mathias Brandt: “Schlafen Sie gut?” , Statista.com, 31.08.2021, online, abgerufen am 01.03.2022
14. Andersen, Lars PH, et al. "Pharmacokinetics of oral and intravenous melatonin in healthy volunteers." BMC Pharmacology and Toxicology 17.1 (2016): 1-5.
15. Herman, Timothy F., and Cynthia Santos. "First pass effect." (2021).
16. Morris, Alyssa L., and Shamim S. Mohiuddin. "Biochemistry, nutrients." (2021).
17. Saha, P. U. J. A., S. U. S. H. M. A. Verma, and PRATIK SWARUP Das. "Sublingual drug delivery: an indication of potential alternative route." International Journal of Current Pharmaceutical Research 9.6 (2017): 5.
18. Bartoli, Antonella Natalia, et al. "Bioavailability of a new oral spray melatonin emulsion compared with a standard oral formulation in healthy volunteers." Journal of Bioequivalence and Bioavailability 4.7 (2012): 96-99.
19. Fundació Eurecat. “Study of the Bioavailability of a Food Supplement Rich in Melatonin Administered Sublingually and Orally”,​​ClinicalTrials.gov Identifier: NCT03951025
20. Peuhkuri, Katri, Nora Sihvola, and Riitta Korpela. "Dietary factors and fluctuating levels of melatonin." Food & nutrition research 56.1 (2012): 17252.
21. Savage RA, Zafar N, Yohannan S, et al. Melatonin. [Updated 2021 Aug 15]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-.
22. West, Kathleen E., et al. "Blue light from light-emitting diodes elicits a dose-dependent suppression of melatonin in humans." Journal of applied physiology (2011).
23. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). EFSA Journal 9.6 (2011): 2241. "Scientific Opinion on the substantiation of a health claim related to melatonin and reduction of sleep onset latency (ID 1698, 1780, 4080) pursuant to Article 13 (1) of Regulation (EC) No 1924/2006."
24. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). EFSA Journal 8.2 (2010): 1467. "Scientific Opinion on the substantiation of health claims related to melatonin and alleviation of subjective feelings of jet lag (ID 1953), and reduction of sleep onset latency, and improvement of sleep quality (ID 1953) pursuant to Article 13 (1) of Reg
25. Matsumoto, Miki, et al. "The amplitude of endogenous melatonin production is not affected by melatonin treatment in humans." Journal of pineal research 22.1 (1997): 42-44.
26. Wright, J., et al. "The effects of exogenous melatonin on endocrine function in man." Clinical endocrinology 24.4 (1986): 375-382.
27. Arendt, J., et al. "Some effects of melatonin and the control of its secretion in humans." Ciba Foundation Symposium. Vol. 117. 1985.
28. Peuhkuri, Katri, Nora Sihvola, and Riitta Korpela. "Dietary factors and fluctuating levels of melatonin." Food & nutrition research 56.1 (2012): 17252.
29. Jung, Hyo Young, et al. "Role of pyridoxine in GABA synthesis and degradation in the hippocampus." Tissue and Cell 61 (2019): 72-78.
30. Thiamin, Riboflavin. "Dietary reference intakes for thiamin, riboflavin, niacin, vitamin B6, folate, vitamin B12, pantothenic acid, biotin, and choline." (1998): 6015.
31. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). EFSA Journal 8.10 (2010): 1759. "Scientific Opinion on the substantiation of health claims related to vitamin B6 and contribution to normal homocysteine metabolism (ID 73, 76, 199), maintenance of normal bone (ID 74), maintenance of normal teeth (ID 74), maintenance of normal hair (ID 7
32. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). EFSA Journal 7.10 (2009): 1225. "Scientific Opinion on the substantiation of health claims related to vitamin B6 and protein and glycogen metabolism (ID 65, 70, 71), function of the nervous system (ID 66), red blood cell formation (ID 67, 72, 186), function of the immune system (ID 68),
33. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). EFSA Journal 8.10 (2010): 1760. "Scientific Opinion on the substantiation of health claims related to folate and contribution to normal psychological functions (ID 81, 85, 86, 88), maintenance of normal vision (ID 83, 87), reduction of tiredness and fatigue (ID 84), cell division (ID 19
34. Tetens, Inge. (2009). "Scientific Opinion on the substantiation of health claims related to folate and blood formation (ID 79), homocysteine metabolism (ID 80), energy-yielding metabolism (ID 90), function of the immune system (ID 91), function of blood vessels (ID 94, 175, 19

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